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Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities

Immunoglobulin repertoires contain a fraction of antibodies that recognize low molecular weight compounds, including some enzymes’ cofactors, such as heme. Here, by using a set of 113 samples with variable region sequences matching clinical-stage antibodies, we demonstrated that a considerable numbe...

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Bibliografiske detaljer
Udgivet i:Commun Biol
Main Authors: Lecerf, Maxime, Kanyavuz, Alexia, Rossini, Sofia, Dimitrov, Jordan D.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988133/
https://ncbi.nlm.nih.gov/pubmed/33758329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01931-7
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