Acitretin reverses early functional network degradation in a mouse model of familial Alzheimer’s disease

Aberrant activity of local functional networks underlies memory and cognition deficits in Alzheimer’s disease (AD). Hyperactivity was observed in microcircuits of mice AD-models showing plaques, and also recently in early stage AD mutants prior to amyloid deposition. However, early functional effect...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Rosales Jubal, Eduardo, Schwalm, Miriam, dos Santos Guilherme, Malena, Schuck, Florian, Reinhardt, Sven, Tose, Amanda, Barger, Zeke, Roesler, Mona K., Ruffini, Nicolas, Wierczeiko, Anna, Schmeisser, Michael J., Schmitt, Ulrich, Endres, Kristina, Stroh, Albrecht
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988040/
https://ncbi.nlm.nih.gov/pubmed/33758244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85912-0
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