Acitretin reverses early functional network degradation in a mouse model of familial Alzheimer’s disease

Aberrant activity of local functional networks underlies memory and cognition deficits in Alzheimer’s disease (AD). Hyperactivity was observed in microcircuits of mice AD-models showing plaques, and also recently in early stage AD mutants prior to amyloid deposition. However, early functional effect...

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Udgivet i:Sci Rep
Main Authors: Rosales Jubal, Eduardo, Schwalm, Miriam, dos Santos Guilherme, Malena, Schuck, Florian, Reinhardt, Sven, Tose, Amanda, Barger, Zeke, Roesler, Mona K., Ruffini, Nicolas, Wierczeiko, Anna, Schmeisser, Michael J., Schmitt, Ulrich, Endres, Kristina, Stroh, Albrecht
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988040/
https://ncbi.nlm.nih.gov/pubmed/33758244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85912-0
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