CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation

Melanoma represents ~5% of all cutaneous malignancies, yet accounts for the majority of skin cancer deaths due to its propensity to metastasise. To develop new therapies, novel target molecules must to be identified and the accessibility of cell surface proteins makes them attractive targets. Using...

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Udgivet i:Commun Biol
Main Authors: van der Weyden, Louise, Harle, Victoria, Turner, Gemma, Offord, Victoria, Iyer, Vivek, Droop, Alastair, Swiatkowska, Agnieszka, Rabbie, Roy, Campbell, Andrew D., Sansom, Owen J., Pardo, Mercedes, Choudhary, Jyoti S., Ferreira, Ingrid, Tullett, Mark, Arends, Mark J., Speak, Anneliese O., Adams, David J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987976/
https://ncbi.nlm.nih.gov/pubmed/33758365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01912-w
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