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The Integration Preference of Sleeping Beauty at Non-TA Site Is Related to the Transposon End Sequences

Recently, we proved that Sleeping Beauty (SB) transposon integrates into non-TA sites at a lower frequency. Here, we performed a further study on the non-TA integration of SB and showed that (1) SB can integrate into non-TA sites in HEK293T cells as well as in mouse cell lines; (2) Both the hyperact...

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Détails bibliographiques
Publié dans:Front Genet
Auteurs principaux: Zhou, Yiting, Ma, Guangwei, Yang, Jiawen, Gao, Zenghong, Guo, Yabin
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987939/
https://ncbi.nlm.nih.gov/pubmed/33777107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2021.639125
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