The plasmablast response to SARS-CoV-2 mRNA vaccination is dominated by non-neutralizing antibodies and targets both the NTD and the RBD

In this study we profiled vaccine-induced polyclonal antibodies as well as plasmablast derived mAbs from individuals who received SARS-CoV-2 spike mRNA vaccine. Polyclonal antibody responses in vaccinees were robust and comparable to or exceeded those seen after natural infection. However, the ratio...

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Xehetasun bibliografikoak
Argitaratua izan da:medRxiv
Egile Nagusiak: Amanat, Fatima, Thapa, Mahima, Lei, Tinting, Sayed Ahmed, Shaza M., Adelsberg, Daniel C., Carreno, Juan Manuel, Strohmeier, Shirin, Schmitz, Aaron J., Zafar, Sarah, Zhou, Julian Q, Rijnink, Willemijn, Alshammary, Hala, Borcherding, Nicholas, Reiche, Ana Gonzalez, Srivastava, Komal, Sordillo, Emilia Mia, van Bakel, Harm, Turner, Jackson S., Bajic, Goran, Simon, Viviana, Ellebedy, Ali H., Krammer, Florian
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987037/
https://ncbi.nlm.nih.gov/pubmed/33758878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.07.21253098
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