The plasmablast response to SARS-CoV-2 mRNA vaccination is dominated by non-neutralizing antibodies and targets both the NTD and the RBD

In this study we profiled vaccine-induced polyclonal antibodies as well as plasmablast derived mAbs from individuals who received SARS-CoV-2 spike mRNA vaccine. Polyclonal antibody responses in vaccinees were robust and comparable to or exceeded those seen after natural infection. However, the ratio...

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Publicat a:medRxiv
Autors principals: Amanat, Fatima, Thapa, Mahima, Lei, Tinting, Sayed Ahmed, Shaza M., Adelsberg, Daniel C., Carreno, Juan Manuel, Strohmeier, Shirin, Schmitz, Aaron J., Zafar, Sarah, Zhou, Julian Q, Rijnink, Willemijn, Alshammary, Hala, Borcherding, Nicholas, Reiche, Ana Gonzalez, Srivastava, Komal, Sordillo, Emilia Mia, van Bakel, Harm, Turner, Jackson S., Bajic, Goran, Simon, Viviana, Ellebedy, Ali H., Krammer, Florian
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987037/
https://ncbi.nlm.nih.gov/pubmed/33758878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.07.21253098
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