SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release

SARS-CoV-2 causes acute respiratory distress that can progress to multiorgan failure and death in some patients. Although severe COVID-19 disease is linked to exuberant inflammation, how SARS-CoV-2 triggers inflammation is not understood. Monocytes are sentinel blood cells that sense invasive infect...

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Publicado no:medRxiv
Main Authors: Junqueira, Caroline, Crespo, Ângela, Ranjbar, Shahin, Ingber, Jacob, Parry, Blair, Ravid, Sagi, de Lacerda, Luna B., Lewandrowski, Mercedes, Clark, Sarah, Ho, Felicia, Vora, Setu M., Leger, Valerie, Beakes, Caroline, Margolin, Justin, Russell, Nicole, Gehrke, Lee, Adhikari, Upasana Das, Henderson, Lauren, Janssen, Erin, Kwon, Douglas, Sander, Chris, Abraham, Jonathan, Filbin, Michael, Goldberg, Marcia B., Wu, Hao, Mehta, Gautam, Bell, Steven, Goldfeld, Anne E., Lieberman, Judy
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987031/
https://ncbi.nlm.nih.gov/pubmed/33758872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.06.21252796
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