A single BNT162b2 mRNA dose elicits antibodies with Fc-mediated effector functions and boost pre-existing humoral and T cell responses

The standard dosing of the Pfizer/BioNTech BNT162b2 mRNA vaccine validated in clinical trials includes two doses administered three weeks apart. While the decision by some public health authorities to space the doses because of limiting supply has raised concerns about vaccine efficacy, data indicat...

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Udgivet i:bioRxiv
Main Authors: Tauzin, Alexandra, Nayrac, Manon, Benlarbi, Mehdi, Gong, Shang Yu, Gasser, Romain, Beaudoin-Bussières, Guillaume, Brassard, Nathalie, Laumaea, Annemarie, Vézina, Dani, Prévost, Jérémie, Anand, Sai Priya, Bourassa, Catherine, Gendron-Lepage, Gabrielle, Medjahed, Halima, Goyette, Guillaume, Niessl, Julia, Tastet, Olivier, Gokool, Laurie, Morrisseau, Chantal, Arlotto, Pascale, Stamatatos, Leonidas, McGuire, Andrew T., Larochelle, Catherine, Uchil, Pradeep, Lu, Maolin, Mothes, Walther, Serres, Gaston De, Moreira, Sandrine, Roger, Michel, Richard, Jonathan, Martel-Laferrière, Valérie, Duerr, Ralf, Tremblay, Cécile, Kaufmann, Daniel E., Finzi, Andrés
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987016/
https://ncbi.nlm.nih.gov/pubmed/33758857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.18.435972
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