Effect of natural mutations of SARS-CoV-2 on spike structure, conformation and antigenicity

New SARS-CoV-2 variants that have accumulated multiple mutations in the spike (S) glycoprotein enable increased transmission and resistance to neutralizing antibodies. Here, we study the antigenic and structural impacts of the S protein mutations from four variants, one that was involved in transmis...

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Vydáno v:bioRxiv
Hlavní autoři: Gobeil, Sophie M-C., Janowska, Katarzyna, McDowell, Shana, Mansouri, Katayoun, Parks, Robert, Stalls, Victoria, Kopp, Megan F., Manne, Kartik, Saunders, Kevin, Edwards, Robert J, Haynes, Barton F., Henderson, Rory C., Acharya, Priyamvada
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986997/
https://ncbi.nlm.nih.gov/pubmed/33758838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.11.435037
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