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Functions for Retinoic Acid-Related Orphan Receptor Alpha (RORα) in the Activation of Macrophages During Lipopolysaccharide-Induced Septic Shock

The transcription factor Related Orphan Receptor Alpha (RORα) plays an important role in regulating circadian rhythm, inflammation, metabolism and cellular development. Herein we show that in the absence of functional RORα in mice there is reduced susceptibility to LPS-induced endotoxic shock, with...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Hams, Emily, Roberts, Joseph, Bermingham, Rachel, Fallon, Padraic G.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986717/
https://ncbi.nlm.nih.gov/pubmed/33767712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.647329
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