Bioprocess performance analysis of novel methanol-independent promoters for recombinant protein production with Pichia pastoris

BACKGROUND: Pichia pastoris is a powerful and broadly used host for recombinant protein production (RPP), where past bioprocess performance has often been directed with the methanol regulated AOX1 promoter (P(AOX1)), and the constitutive GAP promoter (P(GAP)). Since promoters play a crucial role in...

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Библиографические подробности
Опубликовано в: :Microb Cell Fact
Главные авторы: Garrigós-Martínez, Javier, Vuoristo, Kiira, Nieto-Taype, Miguel Angel, Tähtiharju, Juha, Uusitalo, Jaana, Tukiainen, Pauliina, Schmid, Christian, Tolstorukov, Ilya, Madden, Knut, Penttilä, Merja, Montesinos-Seguí, José Luis, Valero, Francisco, Glieder, Anton, Garcia-Ortega, Xavier
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2021
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986505/
https://ncbi.nlm.nih.gov/pubmed/33757505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-021-01564-9
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