Bioprocess performance analysis of novel methanol-independent promoters for recombinant protein production with Pichia pastoris

BACKGROUND: Pichia pastoris is a powerful and broadly used host for recombinant protein production (RPP), where past bioprocess performance has often been directed with the methanol regulated AOX1 promoter (P(AOX1)), and the constitutive GAP promoter (P(GAP)). Since promoters play a crucial role in...

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Detalhes bibliográficos
Publicado no:Microb Cell Fact
Main Authors: Garrigós-Martínez, Javier, Vuoristo, Kiira, Nieto-Taype, Miguel Angel, Tähtiharju, Juha, Uusitalo, Jaana, Tukiainen, Pauliina, Schmid, Christian, Tolstorukov, Ilya, Madden, Knut, Penttilä, Merja, Montesinos-Seguí, José Luis, Valero, Francisco, Glieder, Anton, Garcia-Ortega, Xavier
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986505/
https://ncbi.nlm.nih.gov/pubmed/33757505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-021-01564-9
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