LLL12B, a small molecule STAT3 inhibitor, induces growth arrest, apoptosis, and enhances cisplatin-mediated cytotoxicity in medulloblastoma cells

Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor and an oncogene product, which plays a pivotal role in tumor progression. Therefore, targeting persistent STAT3 signaling directly is an attractive anticancer strategy. The aim of this study is to test the efficacy...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Chen, Xiang, Pan, Li, Wei, Jia, Zhang, Ruijie, Yang, Xiaozhi, Song, Jinhua, Bai, Ren-Yuan, Fu, Shengling, Pierson, Christopher R., Finlay, Jonathan L., Li, Chenglong, Lin, Jiayuh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985203/
https://ncbi.nlm.nih.gov/pubmed/33753770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85888-x
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