Mechanisms of Action of Hypomethylating Agents: Endogenous Retroelements at the Epicenter

Abnormal DNA methylation patterns are thought to drive the pathobiology of high-risk myelodysplastic syndromes (HR-MDS) and acute myeloid leukemia (AML). Sixteen years after their initial approval, the hypomethylating agents (HMAs), 5-azacytidine (AZA) and 5-aza-2′-deoxycytidine, remain the mainstay...

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Udgivet i:Front Oncol
Main Authors: Kordella, Chryssoula, Lamprianidou, Eleftheria, Kotsianidis, Ioannis
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Oncology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985079/
https://ncbi.nlm.nih.gov/pubmed/33768008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.650473
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