Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression

BACKGROUND: Myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) are characterised by abnormal epigenetic repression and differentiation of bone marrow haematopoietic stem cells (HSCs). Drugs that reverse epigenetic repression, such as 5-azacytidine (5-AZA), induce haematological improv...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Kazachenka, Anastasiya, Young, George R., Attig, Jan, Kordella, Chrysoula, Lamprianidou, Eleftheria, Zoulia, Emmanuela, Vrachiolias, George, Papoutselis, Menelaos, Bernard, Elsa, Papaemmanuil, Elli, Kotsianidis, Ioannis, Kassiotis, George
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929315/
https://ncbi.nlm.nih.gov/pubmed/31870430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-019-0707-x
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