Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist

Immune regulation is a finely balanced process of positive and negative signals. PD-L1 and its receptor PD-1 are critical regulators of autoimmune, antiviral and antitumoural T cell responses. Although the function of its predominant membrane-bound form is well established, the source and biological...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:eLife
Main Authors: Ng, Kevin W, Attig, Jan, Young, George R, Ottina, Eleonora, Papamichos, Spyros I, Kotsianidis, Ioannis, Kassiotis, George
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2019
Teme:
Chromosomes and Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877088/
https://ncbi.nlm.nih.gov/pubmed/31729316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50256
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