The clinical applicability of polygenic risk scores for LDL-cholesterol: considerations, current evidence and future perspectives

The current review describes the development, clinical relevance and potential caveats of polygenic risk scores (PRS) for LDL cholesterol (LDL-C). RECENT FINDINGS: In recent years, a large number of common variants have been shown to have a small effect on LDL-C levels. The aggregate effect of all o...

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Bibliografiske detaljer
Udgivet i:Curr Opin Lipidol
Main Authors: Cupido, Arjen J., Tromp, Tycho R., Hovingh, G. Kees
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2021
Fag:
GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7984749/
https://ncbi.nlm.nih.gov/pubmed/33560669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MOL.0000000000000741
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