ADP-Ribosylation Regulates the Signaling Function of IFN-γ

Murine T cells express the GPI-anchored ADP-ribosyltransferase 2.2 (ARTC2.2) on the cell surface. In response to T cell activation or extracellular NAD(+) or ATP-mediated gating of the P2X7 ion channel ARTC2.2 is shed from the cell surface as a soluble enzyme. Shedding alters the target specificity...

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Udgivet i:Front Immunol
Main Authors: Menzel, Stephan, Koudelka, Tomas, Rissiek, Björn, Haag, Friedrich, Meyer-Schwesinger, Catherine, Tholey, Andreas, Koch-Nolte, Friedrich
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7983947/
https://ncbi.nlm.nih.gov/pubmed/33763084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.642545
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