Individualized Dosing of Fluoropyrimidine‐Based Chemotherapy to Prevent Severe Fluoropyrimidine‐Related Toxicity: What Are the Options?

Fluoropyrimidines are widely used in the treatment of several types of solid tumors. Although most often well tolerated, severe toxicity is encountered in ~ 20–30% of the patients. Individualized dosing for these patients can reduce the incidence of severe fluoropyrimidine‐related toxicity. However,...

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Udgivet i:Clin Pharmacol Ther
Main Authors: Knikman, Jonathan E., Gelderblom, Hans, Beijnen, Jos H., Cats, Annemieke, Guchelaar, Henk‐Jan, Henricks, Linda M.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7983939/
https://ncbi.nlm.nih.gov/pubmed/33020924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2069
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