Diagnostic and Therapeutic Strategies for Fluoropyrimidine Treatment of Patients Carrying Multiple DPYD Variants

DPYD genotyping prior to fluoropyrimidine treatment is increasingly implemented in clinical care. Without phasing information (i.e., allelic location of variants), current genotype-based dosing guidelines cannot be applied to patients carrying multiple DPYD variants. The primary aim of this study is...

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Detalhes bibliográficos
Publicado no:Genes (Basel)
Main Authors: Lunenburg, Carin A. T. C., Henricks, Linda M., van Kuilenburg, André B. P., Mathijssen, Ron H. J., Schellens, Jan H. M., Gelderblom, Hans, Guchelaar, Henk-Jan, Swen, Jesse J.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6316498/
https://ncbi.nlm.nih.gov/pubmed/30487465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes9120585
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