A Novel DPYD Variant Associated With Severe Toxicity of Fluoropyrimidines: Role of Pre-emptive DPYD Genotype Screening

Background: The fluoropyrimidine anticancer drug, especially 5- fluorouracil (5-FU) and its prodrug capecitabine are still being the backbone of chemotherapeutic regimens for colorectal cancer. Dihydropyrimidine dehydrogenase (DPD) is the crucial enzyme in the catabolism of 5-FU. Over the past 30 ye...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Tong, Chi C., Lam, Ching W., Lam, Ka O., Lee, Victor H. F., Luk, Mai-Yee
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066555/
https://ncbi.nlm.nih.gov/pubmed/30087856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00279
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