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Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity

BACKGROUND: We investigated the predictive value of dihydropyrimidine dehydrogenase (DPD) phenotype, measured as pretreatment serum uracil and dihydrouracil concentrations, for severe as well as fatal fluoropyrimidine-associated toxicity in 550 patients treated previously with fluoropyrimidines duri...

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Bibliografske podrobnosti
izdano v:Br J Cancer
Main Authors: Meulendijks, Didier, Henricks, Linda M, Jacobs, Bart A W, Aliev, Abidin, Deenen, Maarten J, de Vries, Niels, Rosing, Hilde, van Werkhoven, Erik, de Boer, Anthonius, Beijnen, Jos H, Mandigers, Caroline M P W, Soesan, Marcel, Cats, Annemieke, Schellens, Jan H M
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Translational Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520099/
https://ncbi.nlm.nih.gov/pubmed/28427087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.94
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