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Tolerance to Opioid‐Induced Respiratory Depression in Chronic High‐Dose Opioid Users: A Model‐Based Comparison With Opioid‐Naïve Individuals

Chronic opioid consumption is associated with addiction, physical dependence, and tolerance. Tolerance results in dose escalation to maintain the desired opioid effect. Intake of high‐dose or potent opioids may cause life‐threatening respiratory depression, an effect that may be reduced by tolerance...

詳細記述

保存先:
書誌詳細
出版年:Clin Pharmacol Ther
主要な著者: Algera, Marijke Hyke, Olofsen, Erik, Moss, Laurence, Dobbins, Robert L., Niesters, Marieke, van Velzen, Monique, Groeneveld, Geert Jan, Heuberger, Jules, Laffont, Celine M., Dahan, Albert
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7983936/
https://ncbi.nlm.nih.gov/pubmed/32865832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2027
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