Tolerance to Opioid‐Induced Respiratory Depression in Chronic High‐Dose Opioid Users: A Model‐Based Comparison With Opioid‐Naïve Individuals

Chronic opioid consumption is associated with addiction, physical dependence, and tolerance. Tolerance results in dose escalation to maintain the desired opioid effect. Intake of high‐dose or potent opioids may cause life‐threatening respiratory depression, an effect that may be reduced by tolerance...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Algera, Marijke Hyke, Olofsen, Erik, Moss, Laurence, Dobbins, Robert L., Niesters, Marieke, van Velzen, Monique, Groeneveld, Geert Jan, Heuberger, Jules, Laffont, Celine M., Dahan, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7983936/
https://ncbi.nlm.nih.gov/pubmed/32865832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2027
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