Reduced concentrations of the B cell cytokine interleukin 38 are associated with cardiovascular disease risk in overweight subjects

The IL‐1 family member IL‐38 (IL1F10) suppresses inflammatory and autoimmune conditions. Here, we report that plasma concentrations of IL‐38 in 288 healthy Europeans correlate positively with circulating memory B cells and plasmablasts. IL‐38 correlated negatively with age (p = 0.02) and was stable...

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Pubblicato in:Eur J Immunol
Autori principali: de Graaf, Dennis M., Jaeger, Martin, van den Munckhof, Inge C. L., ter Horst, Rob, Schraa, Kiki, Zwaag, Jelle, Kox, Matthijs, Fujita, Mayumi, Yamauchi, Takeshi, Mercurio, Laura, Madonna, Stefania, Rutten, Joost H.W., de Graaf, Jacqueline, Riksen, Niels P., van de Veerdonk, Frank L., Netea, Mihai G., Joosten, Leo A.B., Dinarello, Charles A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Allergy and inflammation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7983920/
https://ncbi.nlm.nih.gov/pubmed/33125159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201948390
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