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Learning from amyloid trials in Alzheimer's disease. A virtual patient analysis using a quantitative systems pharmacology approach
BACKGROUND: Many trials of amyloid‐modulating agents fail to improve cognitive outcome in Alzheimer's disease despite substantial reduction of amyloid β levels. METHODS: We applied a mechanism‐based Quantitative Systems Pharmacology model exploring the pharmacodynamic interactions of apolipopro...
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| 發表在: | Alzheimers Dement |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
John Wiley and Sons Inc.
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7983876/ https://ncbi.nlm.nih.gov/pubmed/32255562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/alz.12082 |
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