A quantitative way to estimate clinical off-target effects for human membrane brain targets in CNS research and development

Por Spiros, Athan, Geerts, Hugo
Publicado no J Exp Pharmacol (2012)

Not all partial dopamine D(2) receptor agonists are the same in treating schizophrenia. Exploring the effects of bifeprunox and aripiprazole using a computer model of a primate str...

Por Spiros, Athan, Carr, Robert, Geerts, Hugo
Publicado em 2010

A computer-based quantitative systems pharmacology model of negative symptoms in schizophrenia: exploring glycine modulation of excitation-inhibition balance

Por Spiros, Athan, Roberts, Patrick, Geerts, Hugo
Publicado em 2014

Assessing the synergy between cholinomimetics and memantine as augmentation therapy in cognitive impairment in schizophrenia. A virtual human patient trial using quantitative syste...

Por Geerts, Hugo, Roberts, Patrick, Spiros, Athan
Publicado no Front Pharmacol (2015)

A Humanized Clinically Calibrated Quantitative Systems Pharmacology Model for Hypokinetic Motor Symptoms in Parkinson’s Disease

Por Roberts, Patrick, Spiros, Athan, Geerts, Hugo
Publicado no Front Pharmacol (2016)

A biophysically realistic computer model of Alzheimer pathology to guide the development of symptomatic drugs

Por Roberts Patrick D, Spiros Athan, Geerts Hugo
Publicado em 2012-07-01

A biophysically realistic computer model of Alzheimer pathology to guide the development of symptomatic drugs

Por Roberts, Patrick D, Spiros, Athan, Geerts, Hugo
Publicado em 2012

Simulations of symptomatic treatments for Alzheimer's disease: computational analysis of pathology and mechanisms of drug action

Por Roberts, Patrick D, Spiros, Athan, Geerts, Hugo
Publicado em 2012

A strategy for developing new treatment paradigms for neuropsychiatric and neurocognitive symptoms in Alzheimer’s disease

Por Geerts, Hugo, Roberts, Patrick, Spiros, Athan, Carr, Robert
Publicado em 2013

Blinded Prospective Evaluation of Computer-Based Mechanistic Schizophrenia Disease Model for Predicting Drug Response

Por Geerts, Hugo, Spiros, Athan, Roberts, Patrick, Twyman, Roy, Alphs, Larry, Grace, Anthony A.
Publicado em 2012