Negative Symptoms in Schizophrenia: Exploring Glutamatergic Modulation Using a Computer-Based Quantitative Systems Pharmacology Approach

Although many antipsychotics can reasonably control positive symptoms in schizophrenia, patients’ return to society is often hindered by negative symptoms and cognitive deficits. As an alternative to animal rodent models that are often not very predictive for the clinical situation, we developed a n...

詳細記述

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書誌詳細
主要な著者: Hugo eGeerts, Athan eSpiros, Patrick eRoberts
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2014-10-01
シリーズ:Frontiers in Pharmacology
主題:
Glycine
Schizophrenia
negative symptoms
Computer Model
Dose-Response Relationship, Drug
オンライン･アクセス:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00229/full
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