Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers

Human papilloma viruses (HPV) are linked to an epidemic increase in oropharyngeal head and neck squamous cell carcinomas (HNSCC), which display viral inactivation of tumor suppressors TP53 and RB1 and rapid regional spread. However, the role of genomic alterations in enabling the modulation of pathw...

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Publicado no:Cancer Res
Main Authors: Zhang, Jialing, Chen, Tony, Yang, Xinping, Cheng, Hui, Späth, Stephan S., Clavijo, Paul E., Chen, Jianhong, Silvin, Christopher, Issaeva, Natalia, Su, Xiulan, Yarbrough, Wendell G., Annunziata, Christina M., Chen, Zhong, Van Waes, Carter
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7983169/
https://ncbi.nlm.nih.gov/pubmed/29921694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0642
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