Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome

Nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH) has reached epidemic proportions with no pharmacological therapy approved. Lower circulating glycine is consistently reported in patients with NAFLD, but the causes for reduced glycine, its role as a causative fac...

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Опубликовано в: :Sci Transl Med
Главные авторы: Rom, Oren, Liu, Yuhao, Liu, Zhipeng, Zhao, Ying, Wu, Jianfeng, Ghrayeb, Alia, Villacorta, Luis, Fan, Yanbo, Chang, Lin, Wang, Lu, Liu, Cai, Yang, Dongshan, Song, Jun, Rech, Jason C., Guo, Yanhong, Wang, Huilun, Zhao, Guizhen, Liang, Wenying, Koike, Yui, Lu, Haocheng, Koike, Tomonari, Hayek, Tony, Pennathur, Subramaniam, Xi, Chuanwu, Wen, Bo, Sun, Duxin, Garcia-Barrio, Minerva T., Aviram, Michael, Gottlieb, Eyal, Mor, Inbal, Liu, Wanqing, Zhang, Jifeng, Chen, Y. Eugene
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7982985/
https://ncbi.nlm.nih.gov/pubmed/33268508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaz2841
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