Cyclodextrin prevents abdominal aortic aneurysm via activation of vascular smooth muscle cell TFEB

BACKGROUND: Abdominal aortic aneurysm (AAA) is a severe aortic disease with a high mortality rate in the event of rupture. Pharmacological therapy is needed to inhibit AAA expansion and prevent aneurysm rupture. Transcription factor EB (TFEB), a master regulator of autophagy and lysosome biogenesis,...

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Gepubliceerd in:Circulation
Hoofdauteurs: Lu, Haocheng, Sun, Jinjian, Liang, Wenying, Chang, Ziyi, Rom, Oren, Zhao, Yang, Zhao, Guizhen, Xiong, Wenhao, Wang, Huilun, Zhu, Tianqing, Guo, Yanhong, Chang, Lin, Garcia-Barrio, Minerva T., Zhang, Jifeng, Chen, Y. Eugene, Fan, Yanbo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606768/
https://ncbi.nlm.nih.gov/pubmed/32354235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.044803
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