Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome

Nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH) has reached epidemic proportions with no pharmacological therapy approved. Lower circulating glycine is consistently reported in patients with NAFLD, but the causes for reduced glycine, its role as a causative fac...

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Publicado no:Sci Transl Med
Main Authors: Rom, Oren, Liu, Yuhao, Liu, Zhipeng, Zhao, Ying, Wu, Jianfeng, Ghrayeb, Alia, Villacorta, Luis, Fan, Yanbo, Chang, Lin, Wang, Lu, Liu, Cai, Yang, Dongshan, Song, Jun, Rech, Jason C., Guo, Yanhong, Wang, Huilun, Zhao, Guizhen, Liang, Wenying, Koike, Yui, Lu, Haocheng, Koike, Tomonari, Hayek, Tony, Pennathur, Subramaniam, Xi, Chuanwu, Wen, Bo, Sun, Duxin, Garcia-Barrio, Minerva T., Aviram, Michael, Gottlieb, Eyal, Mor, Inbal, Liu, Wanqing, Zhang, Jifeng, Chen, Y. Eugene
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7982985/
https://ncbi.nlm.nih.gov/pubmed/33268508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaz2841
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