Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling

BACKGROUND: Severe asthma is a chronic lung disease characterised by inflammation, airway hyperresponsiveness (AHR) and airway remodelling. The molecular mechanisms underlying uncontrolled airway smooth muscle cell (aSMC) proliferation involved in pulmonary remodelling are still largely unknown. Sma...

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Detalhes bibliográficos
Publicado no:Thorax
Main Authors: Dilasser, Florian, Rose, Lindsay, Hassoun, Dorian, Klein, Martin, Rousselle, Morgane, Brosseau, Carole, Guignabert, Christophe, Taillé, Camille, Dombret, Marie Christine, Di Candia, Leonarda, Heddebaut, Nicolas, Bouchaud, Gregory, Pretolani, Marina, Magnan, Antoine, Loirand, Gervaise, Sauzeau, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Asthma
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7982925/
https://ncbi.nlm.nih.gov/pubmed/33542087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2020-216271
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