Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling

BACKGROUND: Severe asthma is a chronic lung disease characterised by inflammation, airway hyperresponsiveness (AHR) and airway remodelling. The molecular mechanisms underlying uncontrolled airway smooth muscle cell (aSMC) proliferation involved in pulmonary remodelling are still largely unknown. Sma...

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Publicado en:Thorax
Autores principales: Dilasser, Florian, Rose, Lindsay, Hassoun, Dorian, Klein, Martin, Rousselle, Morgane, Brosseau, Carole, Guignabert, Christophe, Taillé, Camille, Dombret, Marie Christine, Di Candia, Leonarda, Heddebaut, Nicolas, Bouchaud, Gregory, Pretolani, Marina, Magnan, Antoine, Loirand, Gervaise, Sauzeau, Vincent
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2021
Materias:
Asthma
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7982925/
https://ncbi.nlm.nih.gov/pubmed/33542087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2020-216271
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