Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1

AKI is a frequent complication in hospitalized patients. Unfortunately, there is no effective pharmacologic approach for treating or preventing AKI. In rodents, mineralocorticoid receptor (MR) antagonism prevents AKI induced by ischemia-reperfusion (IR). We investigated the specific role of vascular...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Barrera-Chimal, Jonatan, André-Grégoire, Gwennan, Nguyen dinh Cat, Aurelie, Lechner, Sebastian M., Cau, Jérôme, Prince, Sonia, Kolkhof, Peter, Loirand, Gervaise, Sauzeau, Vincent, Hauet, Thierry, Jaisser, Frédéric
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2017
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373452/
https://ncbi.nlm.nih.gov/pubmed/28087726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016040477
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