Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase N Terminus Is Indispensable for Proteolytic Activity but Not for Enzyme Dimerization: BIOCHEMICAL AND THERMODYNAMIC INVESTIGATION IN CONJUNCTION WITH MOLECULAR DYNAMICS SIMULATIONS

Severe acute respiratory syndrome (SARS) coronavirus is a novel human coronavirus and is responsible for SARS infection. SARS coronavirus 3C-like proteinase (SARS 3CL(pro)) plays key roles in viral replication and transcription and is an attractive target for anti-SARS drug discovery. In this report...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Chen, Shuai, Chen, Lili, Tan, Jinzhi, Chen, Jing, Du, Li, Sun, Tao, Shen, Jianhua, Chen, Kaixian, Jiang, Hualiang, Shen, Xu
Formato: Artigo
Idioma:Inglês
Publicado em: ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. 2005
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7982548/
https://ncbi.nlm.nih.gov/pubmed/15507456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M408211200
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