pH-dependent Conformational Flexibility of the SARS-CoV Main Proteinase (M(pro)) Dimer: Molecular Dynamics Simulations and Multiple X-ray Structure Analyses

The SARS coronavirus main proteinase (M(pro)) is a key enzyme in the processing of the viral polyproteins and thus an attractive target for the discovery of drugs directed against SARS. The enzyme has been shown by X-ray crystallography to undergo significant pH-dependent conformational changes. Her...

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Publicado no:J Mol Biol
Main Authors: Tan, Jinzhi, Verschueren, Koen H.G., Anand, Kanchan, Shen, Jianhua, Yang, Maojun, Xu, Yechun, Rao, Zihe, Bigalke, Janna, Heisen, Burkhard, Mesters, Jeroen R., Chen, Kaixian, Shen, Xu, Jiang, Hualiang, Hilgenfeld, Rolf
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7094468/
https://ncbi.nlm.nih.gov/pubmed/16242152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2005.09.012
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