Residues on the Dimer Interface of SARS Coronavirus 3C-like Protease: Dimer Stability Characterization and Enzyme Catalytic Activity Analysis

3C-like protease (3CL(pro)) plays pivotal roles in the life cycle of severe acute respiratory syndrome coronavirus (SARS-CoV) and only the dimeric protease is proposed as the functional form. Guided by the crystal structure and molecular dynamics simulations, we performed systematic mutation analyse...

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Detalles Bibliográficos
Publicado en:J Biochem
Autores principales: Chen, Shuai, Zhang, Jian, Hu, Tiancen, Chen, Kaixian, Jiang, Hualiang, Shen, Xu
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2008
Materias:
Regular Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7109808/
https://ncbi.nlm.nih.gov/pubmed/18182387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jb/mvm246
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