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Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure()

The 3C-like protease of SARS coronavirus (SARS-CoV 3CL(pro)) is vital for SARS-CoV replication and is a promising drug target. It has been extensively proved that only the dimeric enzyme is active. Here we discovered that two adjacent mutations (Ser139_Ala and Phe140_Ala) on the dimer interface resu...

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書誌詳細
出版年:Virology
主要な著者: Hu, Tiancen, Zhang, Yu, Li, Lianwei, Wang, Kuifeng, Chen, Shuai, Chen, Jing, Ding, Jianping, Jiang, Hualiang, Shen, Xu
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier Inc. 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7103376/
https://ncbi.nlm.nih.gov/pubmed/19409595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2009.03.034
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