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Inhibition of TLR4/MAPKs Pathway Contributes to the Protection of Salvianolic Acid A Against Lipotoxicity-Induced Myocardial Damage in Cardiomyocytes and Obese Mice

The occurrence of lipotoxicity during obesity-associated cardiomyopathy is detrimental to health. Salvianolic acid A (SAA), a natural polyphenol extract of Salvia miltiorrhiza Bunge (Danshen in China), is known to be cardioprotective. However, its clinical benefits against obesity-associated cardiom...

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Détails bibliographiques
Publié dans:Front Pharmacol
Auteurs principaux: Yang, Zhen, Chen, Yanli, Yan, Zhaoyuan, Xu, Tian Tian, Wu, Xiangyao, Pi, Aiwen, Liu, Qingsheng, Chai, Hui, Li, Songtao, Dou, Xiaobing
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7982403/
https://ncbi.nlm.nih.gov/pubmed/33762947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.627123
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