Ferulic acid alleviates lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML-12 hepatocytes

BACKGROUND: Lipotoxicity-induced cell death plays a detrimental role in the pathogenesis of metabolic diseases. Ferulic acid, widespread in plant-based food, is a radical scavenger with multiple bioactivities. However, the benefits of ferulic acid against hepatic lipotoxicity are largely unclear. He...

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Detalhes bibliográficos
Publicado no:Nutr Metab (Lond)
Main Authors: Xu, Tiantian, Song, Qing, Zhou, Li, Yang, Wenwen, Wu, Xiangyao, Qian, Qianyu, Chai, Hui, Han, Qiang, Pan, Hongzhi, Dou, Xiaobing, Li, Songtao
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814733/
https://ncbi.nlm.nih.gov/pubmed/33468182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12986-021-00540-9
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