Ferulic acid alleviates lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML-12 hepatocytes

BACKGROUND: Lipotoxicity-induced cell death plays a detrimental role in the pathogenesis of metabolic diseases. Ferulic acid, widespread in plant-based food, is a radical scavenger with multiple bioactivities. However, the benefits of ferulic acid against hepatic lipotoxicity are largely unclear. He...

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Dettagli Bibliografici
Pubblicato in:Nutr Metab (Lond)
Autori principali: Xu, Tiantian, Song, Qing, Zhou, Li, Yang, Wenwen, Wu, Xiangyao, Qian, Qianyu, Chai, Hui, Han, Qiang, Pan, Hongzhi, Dou, Xiaobing, Li, Songtao
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814733/
https://ncbi.nlm.nih.gov/pubmed/33468182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12986-021-00540-9
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