Inhibition of EZH2 by chidamide exerts antileukemia activity and increases chemosensitivity through Smo/Gli-1 pathway in acute myeloid leukemia

BACKGROUND: Epigenetic dysregulation plays important roles in leukemogenesis and the progression of acute myeloid leukemia (AML). Histone acetyltransferases (HATs) and histone deacetylases (HDACs) reciprocally regulate the acetylation and deacetylation of nuclear histones. Aberrant activation of HDA...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Transl Med
Autori principali: Jiang, Xuejie, Jiang, Ling, Cheng, Jiaying, Chen, Fang, Ni, Jinle, Yin, Changxin, Wang, Qiang, Wang, Zhixiang, Fang, Dan, Yi, Zhengshan, Yu, Guopan, Zhong, Qingxiu, Carter, Bing Z., Meng, Fanyi
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7981995/
https://ncbi.nlm.nih.gov/pubmed/33743723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-021-02789-3
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi