Inhibition of EZH2 by chidamide exerts antileukemia activity and increases chemosensitivity through Smo/Gli-1 pathway in acute myeloid leukemia

BACKGROUND: Epigenetic dysregulation plays important roles in leukemogenesis and the progression of acute myeloid leukemia (AML). Histone acetyltransferases (HATs) and histone deacetylases (HDACs) reciprocally regulate the acetylation and deacetylation of nuclear histones. Aberrant activation of HDA...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Jiang, Xuejie, Jiang, Ling, Cheng, Jiaying, Chen, Fang, Ni, Jinle, Yin, Changxin, Wang, Qiang, Wang, Zhixiang, Fang, Dan, Yi, Zhengshan, Yu, Guopan, Zhong, Qingxiu, Carter, Bing Z., Meng, Fanyi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7981995/
https://ncbi.nlm.nih.gov/pubmed/33743723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-021-02789-3
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