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Designed leucine‐rich repeat proteins bind two muramyl dipeptide ligands

Designed protein receptors hold diagnostic and therapeutic promise. We now report the design of five consensus leucine‐rich repeat proteins (CLRR4–8) based on the LRR domain of nucleotide‐binding oligomerization domain (NOD)‐like receptors involved in the innate immune system. The CLRRs bind muramyl...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Protein Sci
Main Authors: Kim, Christina S., Brown, Anne M., Grove, Tijana Z., Etzkorn, Felicia A.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Inc. 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980508/
https://ncbi.nlm.nih.gov/pubmed/33512005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.4031
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