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Structure of human Na(v)1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome
Na(v)1.5 is the primary voltage-gated Na(+) (Na(v)) channel in the heart. Mutations of Na(v)1.5 are associated with various cardiac disorders exemplified by the type 3 long QT syndrome (LQT3) and Brugada syndrome (BrS). E1784K is a common mutation that has been found in both LQT3 and BrS patients. H...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7980460/ https://ncbi.nlm.nih.gov/pubmed/33712541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2100069118 |
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