Comparative structural analysis of human Na(v)1.1 and Na(v)1.5 reveals mutational hotspots for sodium channelopathies

Among the nine subtypes of human voltage-gated sodium (Na(v)) channels, the brain and cardiac isoforms, Na(v)1.1 and Na(v)1.5, each carry more than 400 missense mutations respectively associated with epilepsy and cardiac disorders. High-resolution structures are required for structure–function relat...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Pan, Xiaojing, Li, Zhangqiang, Jin, Xueqin, Zhao, Yanyu, Huang, Gaoxingyu, Huang, Xiaoshuang, Shen, Zilin, Cao, Yong, Dong, Mengqiu, Lei, Jianlin, Yan, Nieng
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980448/
https://ncbi.nlm.nih.gov/pubmed/33712547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2100066118
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