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Protein sequence design by conformational landscape optimization

The protein design problem is to identify an amino acid sequence that folds to a desired structure. Given Anfinsen’s thermodynamic hypothesis of folding, this can be recast as finding an amino acid sequence for which the desired structure is the lowest energy state. As this calculation involves not...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Norn, Christoffer, Wicky, Basile I. M., Juergens, David, Liu, Sirui, Kim, David, Tischer, Doug, Koepnick, Brian, Anishchenko, Ivan, Baker, David, Ovchinnikov, Sergey
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980421/
https://ncbi.nlm.nih.gov/pubmed/33712545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2017228118
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