S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD

Rare genetic mutations result in aggregation and spreading of cognate proteins in neurodegenerative disorders; however, in the absence of mutation (i.e., in the vast majority of “sporadic” cases), mechanisms for protein misfolding/aggregation remain largely unknown. Here, we show environmentally ind...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Pirie, Elaine, Oh, Chang-ki, Zhang, Xu, Han, Xuemei, Cieplak, Piotr, Scott, Henry R., Deal, Amanda K., Ghatak, Swagata, Martinez, Fernando J., Yeo, Gene W., Yates, John R., Nakamura, Tomohiro, Lipton, Stuart A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980404/
https://ncbi.nlm.nih.gov/pubmed/33692125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021368118
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