Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors

Reactive oxygen species (ROS) can cause cellular damage and promote cancer development. Besides such harmful consequences of overproduction of ROS, all cells utilize ROS for signaling purposes and stabilization of cell homeostasis. In particular, the latter is supported by the NADPH oxidase 4 (Nox4)...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Helfinger, Valeska, Freiherr von Gall, Florian, Henke, Nina, Kunze, Michael M., Schmid, Tobias, Rezende, Flavia, Heidler, Juliana, Wittig, Ilka, Radeke, Heinfried H., Marschall, Viola, Anderson, Karen, Shah, Ajay M., Fulda, Simone, Brüne, Bernhard, Brandes, Ralf P., Schröder, Katrin
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980388/
https://ncbi.nlm.nih.gov/pubmed/33836590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020152118
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